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Jon I Williams Selected Research

squalamine

12/2005Apparent receptor-mediated activation of Ca2+-dependent conductive Cl- transport by shark-derived polyaminosterols.
7/2004Regression of retinopathy by squalamine in a mouse model.
9/2003A phase I/IIA trial of continuous five-day infusion of squalamine lactate (MSI-1256F) plus carboplatin and paclitaxel in patients with advanced non-small cell lung cancer.
7/2003A Phase I and pharmacokinetic study of squalamine, an aminosterol angiogenesis inhibitor.
4/2002Squalamine and cisplatin block angiogenesis and growth of human ovarian cancer cells with or without HER-2 gene overexpression.

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Jon I Williams Research Topics

Disease

8Pruritus (Itching)
01/2018 - 09/2009
8Allergic Conjunctivitis (Giant Papillary Conjunctivitis)
01/2018 - 09/2009
3Inflammation (Inflammations)
08/2020 - 10/2010
3Hyperemia
08/2011 - 09/2009
3Neoplasms (Cancer)
12/2005 - 04/2002
2Cataract (Cataracts)
08/2020 - 10/2018
2Choroidal Neovascularization
12/2005 - 12/2003
1Retinal Perforations
01/2020
1Vitreous Hemorrhage
01/2020
1Vitreous Detachment (Posterior Vitreous Detachment)
01/2020
1Pain (Aches)
10/2018
1Rhinorrhea
07/2010
1Macular Degeneration (Age-Related Maculopathy)
12/2005
1Insulin Resistance
12/2005
1Retinal Neovascularization
07/2004
1Eye Diseases (Eye Disease)
12/2003
1Wounds and Injuries (Trauma)
12/2003
1Myalgia
09/2003
1Neutropenia
09/2003
1Pleural Effusion (Pleural Effusions)
09/2003
1Non-Small-Cell Lung Carcinoma (Carcinoma, Non-Small Cell Lung)
09/2003
1Arthralgia (Joint Pain)
09/2003
1Hyperbilirubinemia
07/2003
1Ovarian Neoplasms (Ovarian Cancer)
04/2002

Drug/Important Bio-Agent (IBA)

8Ophthalmic Solutions (Eye Drops)IBA
01/2018 - 09/2009
8bepotastine besilateFDA Link
01/2018 - 09/2009
6AllergensIBA
05/2013 - 09/2009
5squalamineIBA
12/2005 - 04/2002
3Histamine Antagonists (Antihistamines)IBA
01/2018 - 09/2009
2Loteprednol Etabonate (Alrex)FDA Link
08/2020 - 10/2018
2Histamine (Histamine Dihydrochloride)FDA Link
05/2013 - 10/2010
2Angiogenesis InhibitorsIBA
12/2005 - 07/2004
2squalamine lactateIBA
12/2003 - 09/2003
1prednisolone acetateFDA LinkGeneric
08/2020
1SuspensionsIBA
08/2020
1Mast Cell StabilizersIBA
05/2013
1Immunoglobulin E (IgE)IBA
05/2012
1Pharmaceutical PreparationsIBA
08/2011
1bepotastineFDA Link
10/2010
1Appetite Depressants (Anorectics)IBA
12/2005
1Oxygen (Dioxygen)IBA
07/2004
1Antineoplastic Agents (Antineoplastics)IBA
12/2003
1Drug CombinationsIBA
09/2003
1Carboplatin (JM8)FDA LinkGeneric
09/2003
1Paclitaxel (Taxol)FDA LinkGeneric
09/2003
1Transaminases (Aminotransferases)IBA
07/2003
1SterolsIBA
04/2002
1Cisplatin (Platino)FDA LinkGeneric
04/2002

Therapy/Procedure

2Drug Therapy (Chemotherapy)
09/2003 - 04/2002
1Intraocular Lenses (Intraocular Lens)
08/2020
1Traction
01/2020
1Vitrectomy
01/2020
1Lasers (Laser)
12/2003
1Aftercare (After-Treatment)
07/2003